Best definition
a derogatory term used universally with all races.
can be used as zyker (ZkY3)as plural or to just be offenive.

guy1: hey that guy headshotedme, u damn zike!

guy2:wat, why call him a zyke?

guy1: cuz the d-bag won’t tell me if he’s black or asian!
zyke: define #2
A slur against male thots.
He was kissing a whole lot of boys last night, he’s definitely a zyke
zyke: define #3
Zyke- A dirty or used q-tip that has been shoved in Donald trumps asshole.
Wow he looks like a zyke. He must be a dirty q-tip