Best definition
You’re killing me smalls
Direct quote from the 1993 film “Sandlot”. After being asked by Ham Porter if he wanted a s’more, Scotty Smalls

replies several times with the question, “Some more what?”. After his frustration grew with Scotty, Ham replies with, “You’re killing me Smalls.” This phrase is commonly used to express discontent or frustration towards a person.

Joe: “Hey Scott, can you pass me another Budweiser?”

Scott: “Actually dude, I just finished the last one.”

Joe: “… You’re killing me smalls.”